The disorder is characterized by stomatitis and vesicular rash on palms of hands and soles of feet. It is caused by Coxsackieviruses A5, 10, 16. The development of mouth sores is most troublesome to adults. The skin lesions are vesicopustules, 0.5 to 5 mm, red-ringed, more oval than round, on palms, sides of fingers and soles.
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